Eredeti cím: Low ambient humidity impairs barrier function and innate resistance against influenza infection
1. Wong GH, Goeddel DV (1986) Tumour necrosis factors alpha and beta inhibit virus
replication and synergize with interferons. Nature 323:819–822.
2. Johnson NB, et al.; Centers for Disease Control and Prevention (CDC) (2014) CDC
National Health Report: Leading causes of morbidity and mortality and associated
behavioral risk and protective factors–United States, 2005-2013. MMWR Suppl 63:3–27.
3. Tamerius JD, et al. (2013) Environmental predictors of seasonal influenza epidemics
across temperate and tropical climates. PLoS Pathog 9:e1003194, and erratum 2013
4. Alonso WJ, et al. (2015) A global map of hemispheric influenza vaccine recommendations
based on local patterns of viral circulation. Sci Rep 5:1–6.
5. Tamerius J, et al. (2011) Global influenza seasonality: Reconciling patterns across
temperate and tropical regions. Environ Health Perspect 119:439–445.
6. Cannell JJ, et al. (2006) Epidemic influenza and vitamin D. Epidemiol Infect 134:1129–
7. Lowen AC, Steel J (2014) Roles of humidity and temperature in shaping influenza
seasonality. J Virol 88:7692–7695.
8. Eccles R (2002) An explanation for the seasonality of acute upper respiratory tract
viral infections. Acta Otolaryngol 122:183–191.
9. Shaman J, Pitzer VE, Viboud C, Grenfell BT, Lipsitch M (2010) Absolute humidity and
the seasonal onset of influenza in the continental United States. PLoS Biol 8:
10. Lowen AC, Mubareka S, Steel J, Palese P (2007) Influenza virus transmission is dependent
on relative humidity and temperature. PLoS Pathog 3:1470–1476.
11. Iwasaki A, Pillai PS (2014) Innate immunity to influenza virus infection. Nat Rev Immunol
12. Chen X, et al. (2018) Host immune response to influenza a virus infection. Front Immunol
13. Garber EA, Hreniuk DL, Scheidel LM, van der Ploeg LHT (1993) Mutations in murine
Mx1: Effects on localization and antiviral activity. Virology 194:715–723.
14. Staeheli P, Grob R, Meier E, Sutcliffe JG, Haller O (1988) Influenza virus-susceptible
mice carry Mx genes with a large deletion or a nonsense mutation. Mol Cell Biol 8:
15. Pillai PS, et al. (2016) Mx1 reveals innate pathways to antiviral resistance and lethal
influenza disease. Science 352:463–466.
16. Taubenberger JK, Morens DM (2008) The pathology of influenza virus infections.
Annu Rev Pathol 3:499–522.
17. Short KR, et al. (2016) Influenza virus damages the alveolar barrier by disrupting
epithelial cell tight junctions. Eur Respir J 47:954–966.
18. Bustamante-Marin XM, Ostrowski LE (2017) Cilia and mucociliary clearance. Cold
Spring Harb Perspect Biol 9:a028241.
19. Verhelst J, Parthoens E, Schepens B, Fiers W, Saelens X (2012) Interferon-inducible
protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein
complex assembly. J Virol 86:13445–13455.
20. Everitt AR, et al.; GenISIS Investigators; MOSAIC Investigators (2012) IFITM3 restricts
the morbidity and mortality associated with influenza. Nature 484:519–523.
21. Brass AL, et al. (2009) The IFITM proteins mediate cellular resistance to influenza A
H1N1 virus, West Nile virus, and dengue virus. Cell 139:1243–1254.
22. Swiecki M, Wang Y, Gilfillan S, Lenschow DJ, Colonna M (2012) Cutting edge: Paradoxical
roles of BST2/tetherin in promoting type I IFN response and viral infection. J
23. Wang X, Hinson ER, Cresswell P (2007) The interferon-inducible protein viperin inhibits
influenza virus release by perturbing lipid rafts. Cell Host Microbe 2:96–105.
24. Lenschow DJ, et al. (2007) IFN-stimulated gene 15 functions as a critical antiviral
molecule against influenza, herpes, and Sindbis viruses. Proc Natl Acad Sci USA 104:
25. Tang Q, Wang X, Gao G (2017) The short form of the zinc finger antiviral protein
inhibits influenza A virus protein expression and is antagonized by the virus-encoded
NS1. J Virol 91:e01909-16.
26. Arnheiter H, Skuntz S, Noteborn M, Chang S, Meier E (1990) Transgenic mice with
intracellular immunity to influenza virus. Cell 62:51–61.
27. Kolb E, Laine E, Strehler D, Staeheli P (1992) Resistance to influenza virus infection of
Mx transgenic mice expressing Mx protein under the control of two constitutive
promoters. J Virol 66:1709–1716.
28. Haller O, Staeheli P, Kochs G (2007) Interferon-induced Mx proteins in antiviral host
defense. Biochimie 89:812–818.
29. Allen EK, et al. (2017) SNP-mediated disruption of CTCF binding at the IFITM3 promoter
is associated with risk of severe influenza in humans. Nat Med 23:975–983.
30. Randolph AG, et al.; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI)
Network Pediatric Influenza (PICFLU) Investigators; Pediatric Acute Lung Injury and
Sepsis Investigators (PALISI) Network Pediatric Influenza (PICFLU) Investigators (2017)
Evaluation of IFITM3 rs12252 association with severe pediatric influenza infection. J
Infect Dis 216:14–21.
31. Mihaylova VT, et al. (2018) Regional differences in airway epithelial cells reveal
tradeoff between defense against oxidative stress and defense against Rhinovirus.
Cell Rep 24:3000–3007.e3.
32. Clary-Meinesz CF, Cosson J, Huitorel P, Blaive B (1992) Temperature effect on the
ciliary beat frequency of human nasal and tracheal ciliated cells. Biol Cell 76:335–338.
33. Daviskas E, et al. (1995) Changes in mucociliary clearance during and after isocapnic
hyperventilation in asthmatic and healthy subjects. Eur Respir J 8:742–751.
34. Oozawa H, et al. (2012) Effect of prehydration on nasal mucociliary clearance in low
relative humidity. Auris Nasus Larynx 39:48–52.
35. Moura FE, Perdigão AC, Siqueira MM (2009) Seasonality of influenza in the tropics: A
distinct pattern in northeastern Brazil. Am J Trop Med Hyg 81:180–183.
36. Shek LP, Lee BW (2003) Epidemiology and seasonality of respiratory tract virus infections
in the tropics. Paediatr Respir Rev 4:105–111.
37. Horisberger MA, Staeheli P, Haller O (1983) Interferon induces a unique protein in
mouse cells bearing a gene for resistance to influenza-virus. Proc Natl Acad Sci USA
38. Grimm D, et al. (2007) Replication fitness determines high virulence of influenza A
virus in mice carrying functional Mx1 resistance gene. Proc Natl Acad Sci USA 104:
39. Mastorakos P, et al. (2015) Highly compacted biodegradable DNA nanoparticles capable
of overcoming the mucus barrier for inhaled lung gene therapy. Proc Natl Acad
Sci USA 112:8720–8725.
40. Francis R, Lo C (2013) Ex vivo method for high resolution imaging of cilia motility in
rodent airway epithelia. J Vis Exp, e50343.
41. Butler A, Hoffman P, Smibert P, Papalexi E, Satija R (2018) Integrating single-cell
transcriptomic data across different conditions, technologies, and species. Nat Biotechnol
42. Cohen M, et al. (2018) Lung single-cell signaling interaction map reveals basophil role
in macrophage imprinting. Cell 175:1031–1044.e18.
43. Steuerman Y, et al. (2018) Dissection of influenza infection In Vivo by single-cell RNA
sequencing. Cell Syst 6:679–691.e4.
44. Kudo E, et al. (2019) Low ambient humidity impairs barrier function, innate resistance
against influenza infection. NCBI BioProject. Available at https://www.ncbi.nlm.nih.gov/
bioproject/PRJNA528197. Deposited March 20, 2019.